This recipe for Chicken and Biscuit Casserole is a spin on one I’ve been making for friends and family since I had my first kitchen in college. Back in those days, we called it “Sexy Casserole,” because it’s the perfect balance between a vegetable-heavy meal and an indulgent splurge. I’m still making this casserole today because it is endlessly versatile—a true “everything but the kitchen sink” kind of meal—and always satisfying.
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Can I substitute…everything?
Yes, you can substitute just about every ingredient in this recipe! That’s why this casserole is an absolute stunner! It can be made at the drop of a hat with whatever you happen to have on hand. For instance:
- Ground chicken: Sub it for ground turkey, pork or beef.
- Vegetables: Use whatever you have in the crisper or freezer. (You just want about 4 cups of chopped vegetables, total.)
- Seasonings: You can use any of your favorite herbs, spices, or seasoning blends.
- Cheese: Try parmesan or pecorino, white cheddar, asiago – or even without cheese!
Do I have to make the biscuits from scratch?
Nope! You don’t have to make the biscuits from scratch! You can buy a boxed mix and add the cheese to the dry ingredients before following the package instructions for suggested bake times and temperatures. Or, make it even easier, and top it with canned biscuits straight from the tube!
Do I really need to use buttermilk?
Nope! Buttermilk isn’t necessary. Any dairy products like heavy cream, half & half, or whole milk will work, too! You can also make a wonderful buttermilk substitute by stirring ¼ tsp lemon juice into ½ cup of milk or cream and let it sit for 1-2 minutes. (And like magic, you have buttermilk!)
If you don’t want to buy buttermilk just for this recipe, you can use the leftovers to make Soda Bread or Blueberry Buttermilk Coffee Cake. Or freeze the leftover buttermilk to use later!
Can I make chicken and biscuit casserole in one pot or pan?
Absolutely! This casserole can be baked right in the same skillet you used on the stovetop–IF that skillet is oven-safe at high temperatures. (No plastic handles, people!) Cast iron or stainless steel skillets are both great options.
Chicken and Biscuit Casserole
Servings 6Ingredients
Casserole Base
- 4 Tbsp salted butter, divided ($0.60)
- 1 lb. ground chicken ($4.49)
- 1/2 tsp red pepper flakes ($0.05)
- 1 tsp rubbed sage ($0.10)
- 1/4 tsp salt ($0.02)
- 1/4 tsp black pepper ($0.02)
- 1 yellow onion, diced ($0.37)
- 2 cloves garlic, minced ($0.16)
- 3 carrots, sliced ($0.19)
- 3 stalks celery, sliced ($0.48)
- 1 cup frozen corn ($0.47)
- 2 Tbsp all-purpose flour ($0.02)
- 1 1/2 cups chicken broth* ($0.18)
Biscuit Topping
- 3 Tbsp salted butter, divided ($0.45)
- 1/2 cup buttermilk ($0.32)
- 2/3 cup all-purpose flour ($0.12)
- 1 tsp baking powder ($0.04)
- 1/2 tsp salt ($0.02)
- 1/2 tsp granulated sugar ($0.01)
- 1/4 tsp black pepper ($0.02)
- 1/2 cup shredded cheddar cheese ($0.62)
Instructions
Casserole Base
- Dice the onion; slice the carrots and celery; mince the garlic; and set the vegetables aside.
- Add 1 Tbsp of butter to a deep-sided skillet and melt over medium heat. Add the ground chicken to the skillet and season with salt, pepper, red pepper flakes, and sage.
- Let the chicken cook, stirring only occasionally to allow time for the chicken to brown. Once fully cooked, remove the chicken from the skillet with a slotted spoon, leaving the extra fat in the pan. If no fat remains, add an additional 1 Tbsp of butter.
- After removing the chicken from the skillet, add the diced onion to the skillet. Saute until the onions are translucent. Add chopped carrots, celery, corn, garlic, and a pinch of salt and pepper. Saute the vegetables for about 5 minutes until the carrots are slightly soft.
- Break the chicken into smaller pieces and add back to the skillet and stir to combine.
- Add 2 Tbsp of butter and 2 Tbsp of flour to the skillet. Stir and cook this mixture for about 2 minutes, continuing to stir until the butter has melted and the flour is coating the vegetables.
- Stir in the chicken broth, making sure to dissolve all of the flour and browned bits off the bottom of the skillet. Bring the broth to a simmer, at which point the broth will thicken slightly. Taste the mixture and adjust seasonings if necessary.
- Remove the skillet from heat and transfer the mixture to a casserole dish. Set aside.
Biscuit Topping
- Preheat the oven to 425°F.
- Add the flour, baking powder, salt, pepper, and sugar to a medium bowl and whisk to combine. Sprinkle grated cheese into dry ingredients and toss to coat.
- Melt 2 Tbsp of butter and stir it into the buttermilk. (It’s okay if the mixture curdles.) Fold the buttermilk mixture into the dry ingredients until just combined.
- Drop dollops of the biscuit mixture evenly around the top of the casserole.
- Cut 1 Tbsp of chilled butter into very small pieces and sprinkle over the biscuits.
- Bake the casserole for about 25 minutes or until the biscuits are golden brown.
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Notes
Nutrition
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How to Make Chicken and biscuit casserole – Step by Step Photos
Add 1 Tbsp of butter to a skillet and melt over medium heat. Add 1 lb. of ground chicken to the skillet and season it with 1/2 tsp red pepper flakes, 1 tsp. rubbed sage, and a pinch of salt and pepper. Cook the chicken, stirring occasionally, until brown. Remove the cooked chicken from the skillet with a slotted spoon, leaving the extra fat behind.
Break the ground chicken into smaller pieces, add back to the skillet, and stir to combine. Add 2 Tbsp of butter and 2 Tbsp of flour to the skillet and stir. Continue to stir and cook until all the butter has melted and the flour coats the vegetables (about 2 minutes).
Stir in 1½ cups of chicken broth, making sure to dissolve all of the flour and browned bits off the bottom of the skillet.
Bring the broth up to a simmer so it has a chance to thicken slightly (about 10 minutes). It will still be slightly soupy! Taste the mixture and adjust seasonings if necessary.
Melt 2 Tbsp of butter and stir it into a 1/2 cup of buttermilk. (It’s okay if the mixture curdles.)
Fold the buttermilk mixture into the dry ingredients.
Stir until just combined, taking care not to overwork the mixture.
This was so delicious and perfect for a stormy evening. I was hoping to have leftovers for lunch but my son needed three bowls to feel full.
I tweaked the filling a bit(frozen peas instead of corn). But the biscuits are the real stars of the dish!
This will be a favourite for the cold season.
Winner! It’s the cheesy biscuit topping that will have me making this one again. I have tried a lot of pot pie and dumpling recipes, and I’m stopping with this one. Drop biscuits are just easier than rolling dough or cutting in butter. I am gluten free and used oat flour which worked great. I used chopped grilled chicken that was waiting to be repurposed. I used a bag of frozen veggies, plus fresh chopped celery. I used a glass 8×11 pan (I think?) and one biscuit recipe covered this well. BUT, the biscuits ARE so good I may do 1.5x the recipe next time just to enjoy the cheesy biscuits more! You can get a little bit in each bite without the whole topping sliding off too.
Did all of this in a dutch oven, no second cooking dish required. I also just chopped up chicken thighs for a more chicken pot pie feel. Absolutely delicious, going in the faves folder for sure.
Great recipe. We make it gluten free with Namaste Flour Blend. I always double the recipe and bake in an 8.5×11 dish. I also recommend upping the biscuit recipe (3x for my doubled filling) to get a better coverage of the dish.
Very good and straight forward recipe! Tasted better the next day. I used a 2.5qt oval casserole dish and doubled the biscuits, which I recommend as I feel it produces a better filling to biscuit ratio. I might reduce the amount of red pepper flakes next time, I am no stranger to spicy foods, but don’t think I loved it in this recipe. Will definitely be making again!
Amazing recipe!!! I used Dolly Parton’s Duncan Hines buttermilk biscuit mix, & just diced up some chicken breast, I didn’t have it ground. Love how versatile this recipe is!!
Another big hit with my family! My husband and son were fighting over the last biscuit. I made this gluten free using my own flour blend, and made made my own buttermilk by adding vinegar to regular milk. Everything came out perfect. I like the idea of adding frozen mixed veggies next time to cut down on prep, especially if I’m short on fresh ingredients. Thank you again!
Thank you for the chicken biscuit casserole, it was easy to make. I sized it up for a crowd and it went over well. I liked the cheese in the biscuits.
Made this last night, and it was as amazing and versatile as promised! Subbed peas for corn, added a parboiled potato chopped into small bits since I had an extra potato laying around, and I didn’t have sage, so added an arbitrary amount of Italian seasoning instead.
I am wondering if it possible to freeze this recipe? Maybe do everything up to putting it in the oven, and stick it in the freezer at that point, and then just bake for a bit longer when actually cooking it? I have an upcoming maternity leave I am prepping for, and would love to add something to the freezer that isn’t just stews haha.
I haven’t tried that, so I’m not sure, but if you do give it a try I would definitely let it thaw completely before baking otherwise it will probably bake very unevenly.